1. Self sufficiency in growth signals
-Secrete growth factors that stimulate own growth
-Increase growth factor receptors
-Cell surface receptor is mutated in the "on" position-constant cell growth/division
2. Insensitivity to antigrowth signals
Antigrowth signals stop unregulated growth- are inactivated in cancer
3. Evading apoptosis (Cell Death)
-Normally apoptosis triggered in response to normal development and excess growth
-Pathway to apoptosis is disabled (mutation of p53)
4.Limitless replicative potential
-Activate telomerase to restore and maintain telomeres at the end of chromosomes
-Protect their chromosomes- retain the ability to divide over and over again
5. Sustained angiogenesis
Stimulate angiogenesis to form their own blood supply- delivers O2 and nutrients
6. Tissue invasion and metastasis
-Specific mutations activate ability of cells to metastasize
-Ex. decreased cell to cell adhesion, secretion of preteases that digest surrrounding barriers, and ability to grow in new locations
Courtesy of Quizlet.com
-Secrete growth factors that stimulate own growth
-Increase growth factor receptors
-Cell surface receptor is mutated in the "on" position-constant cell growth/division
2. Insensitivity to antigrowth signals
Antigrowth signals stop unregulated growth- are inactivated in cancer
3. Evading apoptosis (Cell Death)
-Normally apoptosis triggered in response to normal development and excess growth
-Pathway to apoptosis is disabled (mutation of p53)
4.Limitless replicative potential
-Activate telomerase to restore and maintain telomeres at the end of chromosomes
-Protect their chromosomes- retain the ability to divide over and over again
5. Sustained angiogenesis
Stimulate angiogenesis to form their own blood supply- delivers O2 and nutrients
6. Tissue invasion and metastasis
-Specific mutations activate ability of cells to metastasize
-Ex. decreased cell to cell adhesion, secretion of preteases that digest surrrounding barriers, and ability to grow in new locations
Courtesy of Quizlet.com
